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Chemically, the active ingredient is a racemic mixture of the (+) and (-) enantiomers of cyclobutanemethanamine, 1-(4-chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)-, hydrochloride, monohydrate, and has an empirical formula of C17H29Cl2NO. The structural formula is shown below:

Sibutramine hydrochloride monohydrate is a white to cream crystalline powder with a solubility of 2.9 mg/mL in pH 5.2 water. Its octanol: water partition coefficient is 30.9 at pH 5.0.

How should this medicine be used ?

Sibutramine comes as a capsule to take by mouth. It is usually taken with or without food once a day. To help you remember to take sibutramine, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sibutramine exactly as directed. Sibutramine can be habit forming. Do not take more or less of it or take it more often or for a longer time than prescribed by your doctor.

Your doctor may start you on a low dose of sibutramine and increase your dose, after you have been taking sibutramine for at least 4 weeks. Your doctor may decrease your dose if you experience certain side effects while you are taking your starting dose.

You will probably lose weight soon after you begin taking sibutramine and following your diet and exercise program. Be sure to monitor your weight, and call your doctor if you do not lose at least 4 pounds (1.8 kilograms) during your first 4 weeks of therapy. Your doctor may wish to change your dose of sibutramine.

Sibutramine may not work for everybody. Tell your doctor how much weight you lose during your treatment with sibutramine. Your doctor may tell you to stop taking sibutramine if you do not lose a certain amount of weight during the first 3 to 6 months of your treatment.

You may not continue to lose weight after your first 6 months of treatment. However, you should continue to take sibutramine even if you have stopped losing weight. If you stop taking sibutramine, you may gain weight. Do not stop taking sibutramine without talking to your doctor.